Robert H Brown Selected Research

Conditioned Culture Media

1/2022

Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.

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Robert H Brown Research Topics

Disease

71	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 04/2024 - 05/2002
15	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2022 - 04/2003
9	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 12/2004
9	Chronic Obstructive Pulmonary Disease (COPD) 01/2023 - 02/2004
7	Disease Progression 10/2022 - 12/2008
7	Miyoshi myopathy 04/2019 - 01/2002
6	type 2B Limb-girdle muscular dystrophy 04/2019 - 12/2003
5	Frontotemporal Dementia (Semantic Dementia) 01/2023 - 11/2007
5	Asthma (Bronchial Asthma) 10/2017 - 02/2004
5	Hereditary Sensory and Autonomic Neuropathies (HSAN) 04/2015 - 11/2002
4	Neuroinflammatory Diseases 04/2024 - 04/2016
4	Nervous System Diseases (Neurological Disorders) 01/2022 - 11/2005
4	Weight Loss (Weight Reduction) 11/2019 - 12/2009
4	Muscular Dystrophies (Muscular Dystrophy) 04/2019 - 12/2003
4	Parkinson Disease (Parkinson's Disease) 12/2011 - 06/2004
4	Neuroblastoma 07/2009 - 03/2004
3	Gliosis 01/2024 - 12/2013
3	Body Weight (Weight, Body) 12/2023 - 04/2016
3	Emphysema 10/2022 - 11/2019
3	Wallerian Degeneration 01/2021 - 07/2012
3	Inflammation (Inflammations) 04/2011 - 03/2009
3	Ischemia 03/2009 - 06/2004
3	Latex Hypersensitivity (Latex Allergy) 03/2005 - 03/2003
2	Hereditary Spastic Paraplegia 01/2021 - 05/2002
2	Obesity 01/2020 - 12/2016
2	Lung Diseases (Lung Disease) 11/2019 - 01/2017
2	Dysferlinopathy 04/2019 - 09/2004
2	Paralysis (Palsy) 10/2016 - 04/2016
2	Traumatic Brain Injuries (Traumatic Brain Injury) 04/2016 - 06/2004
2	Distal Myopathies (Distal Muscular Dystrophy) 09/2014 - 06/2011
2	Sarcoma (Soft Tissue Sarcoma) 04/2014 - 11/2010
2	Mitochondrial Diseases (Mitochondrial Disease) 11/2013 - 08/2010
2	Bronchial Spasm 11/2011 - 05/2007
2	Hypersensitivity (Allergy) 05/2010 - 03/2005
2	Alzheimer Disease (Alzheimer's Disease) 11/2007 - 12/2004
2	Hypercapnia 11/2005 - 10/2004
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2023
1	Genomic Instability 01/2023
1	Intellectual Disability (Idiocy) 12/2022
1	Pulmonary Emphysema 10/2022
1	Polyps 01/2022

Drug/Important Bio-Agent (IBA)

21	Proteins (Proteins, Gene)FDA Link 01/2024 - 01/2004
18	Superoxide Dismutase-1IBA 01/2024 - 06/2003
9	Biomarkers (Surrogate Marker)IBA 04/2024 - 12/2005
9	Superoxide DismutaseIBA 11/2022 - 05/2002
8	DysferlinIBA 04/2019 - 01/2002
5	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 11/2012
5	CopperIBA 11/2010 - 05/2002
4	EnzymesIBA 01/2024 - 11/2005
4	DNA-Binding Proteins (DNA Binding Protein)IBA 12/2023 - 09/2012
4	SphingolipidsIBA 07/2021 - 11/2002
4	ZincIBA 11/2010 - 05/2002
4	Rubber (Elastica)IBA 05/2010 - 03/2003
4	LatexIBA 05/2010 - 03/2003
3	LeptinIBA 01/2020 - 10/2004
3	Messenger RNA (mRNA)IBA 12/2019 - 11/2007
3	Profilins (Profilin)IBA 10/2016 - 08/2012
3	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 12/2009 - 11/2006
2	Protein Isoforms (Isoforms)IBA 01/2024 - 11/2007
2	salicylhydroxamic acid (SHAM)IBA 12/2023 - 11/2016
2	Protein Disulfide-IsomerasesIBA 12/2022 - 07/2015
2	DisulfidesIBA 12/2022 - 05/2004
2	Losartan (Cozaar)FDA LinkGeneric 10/2022 - 10/2021
2	Angiotensin Receptor AntagonistsIBA 10/2022 - 10/2021
2	Nerve Growth Factors (Neurotrophins)IBA 01/2022 - 12/2019
2	ArsenicIBA 01/2020 - 11/2019
2	Hormones (Hormone)IBA 01/2020 - 12/2016
2	MicroRNAs (MicroRNA)IBA 01/2020 - 04/2016
2	Morphine (MS Contin)FDA LinkGeneric 01/2020 - 12/2016
2	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 01/2017 - 12/2009
2	AnnexinsIBA 01/2017 - 12/2003
2	Opioid Analgesics (Opioids)IBA 12/2016 - 12/2015
2	Carbon DioxideIBA 12/2016 - 03/2013
2	Interleukin Receptors (Interleukin Receptor)IBA 04/2016 - 07/2012
2	GoldIBA 02/2013 - 09/2008
2	Methacholine Chloride (Methacholine)FDA Link 01/2013 - 09/2008
2	angiogeninIBA 12/2011 - 04/2006
2	Interleukin-13IBA 05/2010 - 03/2005
2	Interleukin-18 (Interleukin 18)IBA 05/2010 - 03/2005
2	Serine C-PalmitoyltransferaseIBA 11/2009 - 11/2002
2	4-phenylbutyric acid (Buphenyl)FDA Link 04/2009 - 06/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2009 - 03/2009
2	Dynactin ComplexIBA 03/2006 - 04/2003
2	CaspasesIBA 06/2005 - 06/2004
1	Protein-Arginine Deiminase Type 2IBA 01/2024
1	Myelin ProteinsIBA 01/2024
1	11-dehydro-thromboxane B2IBA 01/2023
1	CD40 Ligand (CD40L)IBA 01/2023
1	Thromboxane A2 (A2, Thromboxane)IBA 01/2023
1	SelectinsIBA 01/2023
1	P-SelectinIBA 01/2023
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2023
1	poly(glycyl-alanyl)IBA 01/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Untranslated Regions (Untranslated Region)IBA 01/2022
1	Conditioned Culture MediaIBA 01/2022

Therapy/Procedure

10	Therapeutics 01/2023 - 03/2010
3	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 01/2021 - 03/2008
2	Axotomy 01/2021 - 07/2012